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Matthew P. Galloway, Ph.D.
Professor
of Psychiatry and Behavioral Neurosciences
Office Address:
Brain Research And Imaging Neurosciences (BRAINS) E mail: mgallow@med.wayne.edu Phone: (313) 577-7598, (313)577-2914 Fax: (313) 993-4269
EDUCATION
Post-Doctoral Training
Professional Appointments
PROFESSIONAL SOCIETIES: Regular member, American College of Neuropsychopharmacology (1997) Regular member, Society for Neuroscience Michigan Chapter: Society for Neuroscience (President 1997-99) SERVICE: CONSULTANT and GRANT REVIEW EXPERIENCE ¨ NIDA: Regular member, NIDA-K, Training and Career Development (Regular member 2/99-6/03; ad hoc 11/03-6/04; reappointed 7/04-6/07)¨ NIDA: Training and Career Development Review Committee (ZDA-MXS-M-01): 4/98 -2/99 ad hoc [interim chair, Nov '98] ¨ NCRR ad hoc (Centers of Biomedical Research Excellence) March 2005 ¨ NIEHS ad hoc (K awards) July 2004¨ Life Sciences Greenhouse of Central Pennsylvania: Grant review 11/03 ¨ NIMH B/START Ad hoc grant review, 1994, 1995, 1996 ¨ NIDA Contract Proposal Review Committee (stimulant screening program, July 1990) ¨ NIDA Scientific Consultant for "CNS stimulants and new drug development" 1/91 - 9/93 ¨ NSF Grant Review (Neuroscience Program, 1990) ¨ NINDS Special Review Committee, Program Project site visit (March 1989) ¨ NINDS Program Project Site Review, Ad Hoc member (May, 1989) ¨ Member, DATATOP Assay Committee (advise multicenter clinical study on biochemical aspects of assays of Parkinsonian CSF and plasma, 1987-1992) UNIVERSITY COMMITTEE SERVICE: (*Department of Psychiatry and Behavioral Neurosciences) *2005-07 Graduate Committee, Masters Training Program in Psychiatry *1994-2000 Departmental Review Board, Chair *1994-96 Joe Young Sr. Research Fund, Chair *1993-95 Executive Committee, (basic science liaison to the Chairman) *1997-00 Director, Office of Research Administration *1996-02 Promotions and Tenure *1995-00 Executive Research Directors Committee *1994-99 Continuing Medical Education *1996-7 Public Relations and Lobbying Task Force *1994- Masters of Science in Psychiatry (Admissions, Program, Graduate) *1990-1992 Graduate Officer, Cellular and Clinical Neurobiology PhD Training Program *1985-92, 94-00 Graduate Committee, Cellular and Clinical Neurobiology PhD Program *1994-5 Departmental clinical research program task forces: Schizophrenia and Mood Disorders, Substance Abuse, Program development *1994-5 Renovations & Budget plan committee (MCHT and DRH) *1990-1992 Executive Committee, Department of Psychiatry *1990,1997 Internal Review Committee (Psychiatry); chair, basic research ('90) *1984-90 Space and Equipment Advisory Committee, Lafayette Clinic *1992 Lafayette Clinic-Wayne State University Transition Committee 2001- Research Development Committee, Medical School Faculty Senate 2001-03 Neuroscience Advisory Board (School of Medicine) 2001 Strategic Planning for the School of Medicine 2001 Perinatal Research Branch Contract, Exec Planning Committee 2001 Committee to Enhance Postdoctoral Studies at WSU 1999 Strategic Planning Retreat: Basic Research & Education (School of Medicine) 1999 Task Force for Non-Human Primate Studies (University) 1994-00 Animal Investigation Committee (University) 1996 Graduate Assistant awards (School of Medicine) 1995 Rumble fellowship review; Graduate Professional fellowship review 1984-90 Neuroscience Program Executive Committee, Wayne State University 1986-1990 Neuroscience Program Seminar Series Committee (Chairman), WSU 1987 Scott Lecture and Neuroscience Colloquium Committee, WSU External committee service: 1997-99 President, Michigan Chapter, Society for Neuroscience 1993-6 Chair, Student Awards Committee, Michigan Chap: Society for Neuroscience 1996 President-elect, Michigan Chapter: Society for Neuroscience 1997,98,99 Brain Awareness Lecture Series (high schools) 1997,98,99,00 Board of Directors, On My Own (independent living for challenged adults) 1997,98, 99,00 President, Board of Trustees, Fox Hills Community Association
TEACHING: (At Wayne State University School of Medicine (1984-present) Graduate: PYC 7010 Molecular Neuropsychopharmacology (Course Director 2002-) IBS 7050 Medical Neurobiology (2005- ) MBG 7091 Scientific Communications (2003- ) PYC 701 Neurobiology I (annually, 1987-2000) PYC 702 Neurobiology II (course director, annually, 1993-2000) PYC 751 Neurochemistry of Monoamine Neurons (course director, 88-98) PYC 789 Seminar (course director, 1988-89) PYC 790 Directed Study PYC 796 Laboratory rotation ANA 719 Neuroscience Survey (1988-91) PHC 701 Pharmacology: 5 lectures, psychopharmacology (1994-96) PHC 755 Advanced Topics in Neurochemical Pharmacology Ph. D Dissertations (M. Galloway, Primary Advisor): Raymond S. Salah, MD, PhD; 5/86 - 7/89, "Regulation of tyrosine hydroxylase activity in the rat striatum" Post doc: Univ of Michigan, Psychiatry residency & research fellow; private practice Camille S. Suchowski (Norton), PhD 4/93- 9/97 Serotonin facilitation of dopamine release: neurochemical anatomy Post-doc: Univ of Michigan Sch Med (Dr. S. Watson); Research Associate MHRC UM Cheryl W. Aretha, PhD 8/93- 5/97 The role of dopamine D3 receptors in the autoregulation of dopamine synthesis Post-doc: Univ of Mich Sch Med (Dr. M. Gnegy); WSU (Dr. D Kuhn); Lecturer, Baker College, Troy, MI (2003-) & Macomb Comm College (2004-) Richard Nassar, PhD 10/93- 9/96 Serotonergic modulation of tyrosine hydroxylase activity: An in vivo microdialysis study Post-doc: Yale Univ Sch Med (Dr. C. Bradberry); Anthony West, PhD 1/94 - 8/97 Characterization of nitric oxide-facilitated striatal dopamine and glutamate release in vivo: Role of ionotropic glutamate receptor -mediated mechanisms Post-doc: Univ of Pittsburgh (Dr. A. Grace); (1997-2002) Assistant Professor Neuroscience, Rosalind Franklin (Finch Univ)-Chicago Med Sch (2002) Susanne Koch, PhD 1/94- 9/98 Modulation of extracellular dopamine levels in rat brain by serotonin preferring psychostimulants and selective serotonin reuptake inhibitors Post-doc: Wayne State Univ Sch Med Brain Imaging (Dr. G. Moore); Research Fellow Lily Research Labs (2000-02, Dr Frank Bymaster) Lecturer, Fresno State College, Fresno, CA (2003- ) Carrol D'Sa, PhD 1/97- 9/98 Characterization of rat brain tryptophan hydroxylase: In vitro and in vivo influence of iron Post-doc: Yale University Sch Med (Dr. R. Duman 1998-2001); Research Associate, Yale Univ (2002) Navid Seraji-Bozorgzad (MD-PhD) 5/04 - Multivariate data analysis, affective disorders, and magnetic resonance spectroscopy Master's Thesis in Basic Medical Sciences (MP Galloway, Primary Advisor) Renee Maan 10/03- Neurochemical profile of cocaine determined with magnetic resonance spectroscopy Kerry Murphy 05/04- Neurochemical profile of injectable and volatile anesthetics with HR-MAS 1H-MRS Joel Frederick 09/04- Review of nicotine cessation strategies Nicolle Aratari 5/98-2000 Potential role of 5HT4 receptor activation in cocaine induced increases in dopamine Current: MD WSU-SOM 2004, Residency Henry Ford 7/04 Partha Mukhopadhyay 5/98-2000 Respective role of dopamine and serotonin transporters in the action of cocaine Current: PhD graduate student (2003) Wisconsin Mark Barsamian 2/94 - 1998 Anxiogenic peptide regulation of dopamine release
Awards and honors for supervised students: Raymond Salah: NIMH NRSA, 9/87, "Control of tyrosine hydroxylase in dopaminergic neurons" F31 MH-09673; Michigan Chapter: Society for Neuroscience, Duncan McCarthy Award, 1988 Camille Suchowski: Michigan Parkinson Foundation, 8/93, "Analysis of cerebrospinal fluid for 5-S-cysteinyl-DOPA and 6-hydroxydopamine"; Bernoucci Fellowship (Psychiatry) for Graduate Support 1995-96. Anthony West: NRSA F31 DA-05767 11/96 (2 yrs) "Regulation of striatal nitric oxide and dopamine release in vivo". WSU Rumble Fellow (94-95); Best poster, Michigan Chapter: Society for Neuroscience meeting '95 Richard Nassar: WSU Rumble Fellow (95-96) Susanne Koch: Best poster, Michigan Chapter: Society for Neuroscience meeting 1994; Duncan McCarthy Best Student Paper Award, 1997 Cheryl Wiley Aretha: Best poster, Michigan Chapter: Society for Neuroscience meeting,'96 Carrol D'Sa: WSU Rumble Fellow Todd Mitchell: NRSA F31 NS-043047 2002-04 “Mood Stabilizers and Neuroprotection” Shonagh K. O'Leary-Moore: NRSA F31 AA-015224 2005-2008 “Neonatal Alcohol Exposure and 1H-NMR Imaging in Rats”
Graduate and Undergraduate Trainees
Postdoctoral TraineesSusan Benloucif, Ph.D. (UC Berkeley) 1/89 - 8/92 Current: Associate Professor, Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL MaryAnn Chapman, Ph.D. (Washington State University) 12/96- 2/99 Current: President, Visage Communications, Spokane, WA External support Active: · R01-DA-016736 National Institute on Drug Abuse; High Field Magnetic Resonance Spectroscopy assessment of stimulant exposure in rats; MP Galloway, PI; GJ Moore, co-I; April 2004-2008; $1,324,000 (TC) · T32-DA-07310 National Institute on Drug Abuse: Training in Substance Abuse; DM Kuhn, PI; MP Galloway et al. co-I. June 2000-2005, $600,000 · R21 DA 019151 National Institute on Drug Abuse: A Preclinical Model of Adolescent Toluene Abuse in Rats SE Bowen, PI; MP Galloway, co-I. Sept 2004-Aug 2006 Pending: · R01 ES 009977 National Institute of Environmental Health Sciences: Lead Toxicity-Midbrain Dopaminergic System, DK Pitts, PI, MP Galloway, consultant, July 2005-June 2009
Completed ProjectsMichael J Fox Foundation for Parkinson Research; Ultra High Field MRS assessment of MPTP, Rotenone, and BSO effects in rodents; MP Galloway, PI; GJ Moore co-I; Jan 2003-11/30/04; $50,000
National Institute on Drug Abuse 7/1/86 - 8/30/99 R01-DA-04120 Cocaine and Amphetamine: Mesocortical Dopamine NeuronsMP Galloway, PI
United Parkinson Foundation 1/1/89 Pilot Studies on Gradient vs. One-Point Analysis of CSF HVAMP Galloway, PINational Institute of Neurological Disorders and Stroke 4/1/90 - 3/31/93 R01 NS-27892 Biological Markers in Parkinsons CSF Peter LeWitt, PI
National Institute of Neurological Disorders and Stroke 7/1/87-6/30/92 NS-24778 Deprenyl/tocopherol antioxidative therapy of Parkinsonism: Subcontract for GC-MS analysis of CSF HVA Ira Shoulson, PI
National Institute of Aging 4/1/88 - 3/30/96 R01 AG-05233 Behavioral treatment of menopausal hot flashes Robert Freedman, PI
National Heart, Lung, and Blood Institute 12/1/88-11/30/93 R01 HL-30604 Behavioral treatment of Reynaud's phenomena Robert Freedman, PI
National Institute on Alcohol Abuse and Alcoholism 12/1/92-11/30/97 P50 AA-07606 Fetal alcohol exposure: From mechanism to prevention Project 3: "Effects on dopaminergic systems" (MP Galloway, PI) Robert Sokol, PI program project
National Institute for Mental Health 8/1/86 ‑ 7/30/89 R01 MH 41227 Serotonin Autoreceptors and Chronic Antidepressants MP Galloway, PI
Pharmaceutical Manufacturers Association Foundation 1/1/86 - 12/31/87 (Researcher Starter grant) Neuropharmacology of presynaptic serotonin neuronsMP Galloway, PI
Neurosciences Program-WSU 7/1/85- 6/30/86 Cocaine: Effects on mesocortical and mesolimbic dopamine neurons MP Galloway, PI
United Parkinson Foundation 1/1/86 ‑ 12/31/86 Dopamine Autoreceptor Sensitivity After Chemical Lesions of Dopamine Neurons MP Galloway, PI
National Institute on Drug Abuse 5/82-5/83 F32-DA05209 Morphine in central noradrenergic systems MP Galloway, PI (RH Roth, mentor)
National Institute for Mental Health 9/83-5/84 F32-MH09102 Biochemical Pharmacology of Neuroleptics MP Galloway, PI (RH Roth, mentor)
SELECTED PUBLICATIONS Roth, B.L., Galloway, M.P., and Coscia, C.J. The effects of morphine on catecholamine metabolism during postnatal development. Brain Res., 197: 561‑564, 1980. Galloway, M.P. Roth, B.L., and Coscia, C.J. The effects of tetrahydroisoquinolinecarboxylic acids on tyrosine‑3‑monooxygenase, Arch. Biochem. Biophys. 209: 620‑627, 1981. Galloway, M.P., Burke, W.J. and Coscia, C.J. Tetrahydroisoquinoline carboxylic acids and catecholamine metabolism in adrenal medulla explants. Biochem. Pharmacol., 31: 3251‑3256, 1982. Galloway, M.P., and Westfall, T.C. The release of endogenous norepinephrine from the coccygeal artery of spontaneously hypertensive and wistar‑kyoto rats. Circ. Res., 51: 225‑232, 1982. Galloway, M.P. and Roth, R.H. Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.J. Neurochem., 40: 246‑251, 1983. Galloway, M.P. and Roth, R.H. The neuropharmacology of 3‑isobutylmethylxanthine: Effects on central noradrenergic systems in vivo. J. Pharmacol. Exp. Therap., 227: 1‑8, 1983. Reinhard, J.F., Jr., Galloway, M.P. and Roth, R.H. Noradrenergic modulation of serotonin synthesis and metabolism II: Stimulation by 3‑isobutyl‑1‑methylxanthine. J. Pharmacol. Exp. Ther.226: 764‑769, 1983. Charney, D.S., Redmond, D.E. Jr., Galloway, M.P., Kleber, H.D., Heninger, G.R., Murberg, M., and Roth, R.H. Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: Evidence for noradrenergic hyperactivity. Life Sci., 35: 1263‑1272, 1984. Charney, D.S., Galloway, M.P., Heninger, G.R. The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans; Life Sci., 35: 135‑144, 1984. Grant, S.J., Galloway, M.P., Mayor, R., Fenerty, J., Finkelstein, M.F., Roth, R.H., and Redmond, D.E. Precipitated diazepam withdrawal elevates noradrenergic metabolite in primate brain. Eur. J. Pharmacol., 107: 127‑132, 1985. Galloway, M.P., Wolf, M.E. and Roth, R.H. Regulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: Studies in vivo. J. Pharmacol. Exp. Ther.,236: 689-698, 1986. Wolf, M.E. Galloway, M.P. and Roth, R.H. Regulation of dopamine synthesis in the medial prefrontal cortex: Studies in brain slices. J. Pharmacol. Exp. Ther., 236: 699-707, 1986. Salah, R.S., Kuhn, D.M., and Galloway, M.P., Dopamine autoreceptors modulate the phosphorylation of tyrosine hydroxylase in rat striatal slices. J. Neurochem. 52: 1517-1522, 1989. Nelson, M.V., Berchou, R.C., LeWitt, P.A., Hussain, M., Kareti, D., Kesaree, N., Schlick, P., and Galloway, M.P. Pharmacokinetic and pharmacodynamic modeling of levodopa plasma concentrations and clinical effects in parkinsons disease after Sinemet, Clinical Neuropharmacol., 12: 91-97, 1989. Martin, S.R. Yergani, V.K., Lohdi, R.A., and Galloway, M.P. Clinical ratings and plasma HVA during cocaine abstinence, Biol. Psychiatry, 26: 356-362, 1989 The Parkinson Study Group, Effect of deprenyl on the progression of disability in early Parkinson's Disease, N. Engl. J. Med., 321: 1364-71, 1989. (MPG: Director, Cerebrospinal Fluid Assay Center; Member, Assay Standards Committee). Wachtel, S.R., Hu, X.T., Galloway, M.P., and White, F.J. D1 Dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems, Synapse, 4: 327-346, 1989. Nelson, M.V., Berchou, R.C., LeWitt, P.A., Kareti, D., and Galloway, M.P. Pharmacodynamic modeling of concentration-effect relationships after controlled-release carbidopa/levodopa (Sinemet CR4) in Parkinson's disease, Neurology, 40: 70-74, 1990. Galloway, M.P. Regulation of dopamine and serotonin synthesis by acute administration of cocaine, Synapse, 6: 63-72, 1990. Hu, X.-T., Wachtel, S.R., Galloway, M.P., and White, F.J. Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation. J. Neurosci., 10: 2318-2329, 1990. Brooderson, R.B., White, F.J., and Galloway, M.P. Inhibition of dopamine synthesis in striatal slices by the D1 agonist SKF 38393 is not mediated by D1 dopamine receptors. Synapse, 6: 395-397, 1990. Clark, D., Salah, R.S., and Galloway, M.P. Differential agonist profile of the enantiomers of 3-PPP at striatal dopamine autoreceptors: Dependence on extracellular dopamine. Synapse, 8: 169-176, 1991. Benloucif, S.B. and Galloway, M.P. Facilitation of dopamine release in vivo by serotonin agonists: Studies with microdialysis. Eur. J. Pharmacol., 200: 1-8, 1991. Tyler, C.B., and Galloway, M.P. Acute administration of amphetamine: Differential regulation of dopamine synthesis in dopamine projection fields. J. Pharmacol. Exp. Ther., 261: 567-73, 1992. LeWitt, P.A., Galloway, M.P., Matson, W., Milbury, P., Srivastava, DK., Oakes, D., and The Parkinson Study Group. Markers of dopamine metabolism in Parkinson's Disease. Neurology, 42:, 2111-2117, 1992. Benloucif, S.B., Keegan, M.J. and Galloway, M.P. Serotonin-facilitated dopamine release in vivo: Pharmacological characterization. J. Pharmacol. Exp. Ther. 265:, 373-377, 1993. Galloway, M.P., Suchowski, C.S., Keegan, M.J., and Hjorth, S. Local infusion of the selective 5HT-1b agonist CP-93,129 facilitates dopamine release in vivo. Synapse 15:, 90-92, 1993. 1993. Freedman, R.R., Keegan, D., Rodriguez, J., and Galloway, M.P Plasma catecholamine levels during temperature biofeedback training in normal subjects. Biofeedback Self Regul. 18 (2): 107-114, 1993. Hjorth, S, Suchowski, CS, and Galloway, MP Evidence for 5HT autoreceptor-mediated, nerve impulse-independent, control of 5HT synthesis in the rat brain. Synapse, 19: 170-176, 1995. Aretha, CW, Sinha, A. and Galloway, MP Dopamine D3-preferring ligands act at synthesis modulating autoreceptors, J. Pharmacol. Exp. Ther. 274:609-613,1995 West, AR and Galloway, MP Regulation of serotonin-facilitated dopamine release in vivo: The role of protein kinase A activating transduction mechanisms: Synapse 23:20-27, 1996 Aretha, CW, and Galloway, MP Dopamine autoreceptor reserve in vitro: possible role of D3 receptors, Eur. J. Pharmacol. 305:119-122, 1996 West, AR and Galloway, MP Intrastriatal infusion of (+)-S-nitroso-N-acetylpenicillamine releases vesicular dopamine via an ionotropic glutamate receptor-mediated mechanism: An in vivo microdialysis study in chloral hydrate anesthetized rats. J. Neurochem. 66:1971-1980, 1996 Norton, CS and Galloway, MP Repeated cocaine exposure attenuates the ability of 5-HT to release striatal dopamine in vivo. Eur. J. Pharmacol. 318:323-326, 1996. Koch, S, Piercey, MF, Galloway, MP, Svensson, KA Interactions between cocaine and (-)-DS 121: Studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain. Eur. J. Pharmacol, 319: 173-180, 1997. Koch, S and Galloway, MP MDMA induced dopamine release in vivo: Role of endogenous serotonin. J. Neural Trans., 104: 135-146, 1997 West, AR and Galloway, MP Endogenous nitric oxide releases striatal dopamine and glutamate in vivo: Role of ionotropic glutamate receptor activation. Neuropharmacol 36: 1571-81, 1997. West, AR and Galloway, MP Inhibition of glutamate reuptake potentiates endogenous nitric oxide-facilitated dopamine efflux in the rat striatum: an in vivo microdialysis study Neurosci. Lett., 229: 21-24, 1997 West AR and Galloway MP Nitric oxide and potassium chloride-facilitated striatal dopamine efflux in vivo: Role of calcium-dependent release mechanisms. Neurochem Int 33: 493-501, 1999 West, AR, Galloway, MP, and Grace AA Regulation of striatal dopamine neurotransmission by nitric oxide: Effector pathways and signaling mechanisms. Synapse, 44: 227-245, 2002 Moore GJ and Galloway MP Magnetic Resonance Spectroscopy: Neurochemistry and Treatment Effects in Affective Disorders. Psychopharmacology Bulletin 36: (2) 1-23, 2002 Chapman MA, Roll JM, Park S, Galloway MP Extracellular glutamate decrease in accumbens following cued food delivery. Neuroreport. 14 (7): 991-4, 2003 Mitchell TR, Seraji-Bozorgzad N, Galloway MP, and Moore GJ. Mood Stabilizers Lithium and Valproic Acid Afford Neuroprotection Against 3-Nitroproprionic Acid in Rats in preparation 2005 Bustillo J, Barrow R, Paz R, Tang J, Seraji-Bozorgzad N, Moore GJ, Perrone-Bizzozero N, Bolognani F, Lauriello J, Galloway MP Long term treatment of rats with Haloperidol: Lack of an effect on N-acetylaspartate Neuropsychopharmacology in press 2005 Mann R, Seraji-Bozorgzad N, Galloway MP. Metabolic Profile of Acute Cocaine in Rat Brain: Analysis with High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy in preparation 2005 REVIEW ARTICLES: Galloway, M.P., Neurochemical interactions of cocaine with dopaminergic systems, Trends Pharmacol. Sci., 9: 451-454, 1988. Galloway, M.P. Augmentation of SSRI antidepressant efficacy with pindolol and the relevance of 5HT1A autoreceptors Anxiety, 2: 149-152, 1996. BOOK CHAPTERSWestfall, T.C., Galloway, M.P. Sax, R.D., Earnhardt, J.T., Leighton, H.J., Role of nerve impulse traffic and hypertension and prejunctional adrenoreceptor function, in Vascular Neuroeffector Mechanisms: 4th International Symposium, p. 117‑124, Ed., J. Bevan, Raven Press, New York, 1983. Bennett, D.B., Galloway, M.P. Coscia, C.J. Interaction of tetrahydroisoquinolines with activated tyrosine hydroxylase, in Beta‑Carbolines and Tetrahydroisoquinolines (Progress in Clinical and Biological Research, vol. 90),pp. 301‑310 Eds., F. Bloom, J. Barchas, M. Sandler, and E. Usdin, Alan R. Liss, Inc., New York, 1982. Billingsley, M.L., Galloway, M.P., and Roth, R.H. Possible role of protein carboxylmethylation in the autoreceptor‑mediated regulation of dopamine neurons. In: Catecholamines, Part B: Neuropharmacology and Central Nervous System‑Theoretical Aspects, Proceedings of the Fifth International Catecholamine Symposium, E.Usdin, A. Carlsson, A. Dahlstrom, and J. Engel, Eds., pp. 37‑41, Alan R. Liss, Inc., NY, 1984. Roth, R.H. Galloway, M.P., Tam, S‑Y, Ono, N., Wolf, M.E. Dopamine autoreceptors: Studies on their distribution and mode of action. In: Dopaminergic Systems and their regulation-IUPHAR Satellite Symposium, Woodruff, G.N., Poat, J.A., Roberts, P.J., Eds., The MacMillan Press, Great Britain, 1986 Levine, R.A. and Galloway, M.P., The regulation of monoamine synthesis and role of tetrahydrobiopterin. In: Unconjugated Pterins in Neurobiology: Basic and Clinical Aspects, W. Lovenberg and R.A. Levine, Eds., pp. 119-130, Taylor and Francis, Inc., London and Philadelphia, PA, 1987. Galloway, M. P. and Levine, R.A., Modulation of Dopamine Synthesis by Nerve Terminal Autoreceptors: A Role for Tetrahydrobiopterin? In: Chemistry and Biology of Pteridines 1986, B.A. Cooper and V.M. Whitehead, Eds., pp. 347-350, Walter de Gruyter & Co., Berlin, New York. 1986 LeWitt, P.A. and Galloway, M.P., Implications of D-1 agonism for anti-parkinsonian therapeutics, In: Recent Developments in Parkinson's Disease Volume II, S. Fahn, C.D. Marsden, D.B. Calne, M. Goldstein, Eds., pp. 75-89, Macmillan Healthcare Information, Florham Park, N.J. 1988 LeWitt, P.A. and Galloway, M.P., Neurochemical markers of Parkinson's Disease, In: Therapeutics in Parkinson Disease, W. Koller and G. Paulson, Eds., pp.63-93, Marcel Dekker Inc., New York, N.Y. 1990. Galloway, M.P. Neuropharmacology of Cocaine: Effects on dopamine and serotonin systems. In Cocaine: Pharmacology, Physiology and Clinical Strategies, J.M. Lakoski, M.P. Galloway, and F.J. White, Eds., pp. 163-189, CRC Press, Boca Raton Inc., FL, 1991. BOOKS EDITEDCocaine: Pharmacology, Physiology and Clinical Strategies, 443 pp. J.M. Lakoski, M.P. Galloway, and F.J. White, Eds., CRC Press, Boca Raton Inc., FL, 1991. RECENT ABSTRACTS (978-2005 = 141) · Galloway MP*, Fricke S, Mitchell TR, Seraji-Bozorgzad N, Moore GJ, MDMA (“Ecstasy”) Increases Striatal but not Prefrontal GABA in Rat Brain: Studies with High-Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HR-MAS 1H-MRS), 10th Ann Mtg of The International Society of Magnetic Resonance in Medicine, Abstract, Hawaii (2002). · Mitchell TR*, Galloway MP, Fricke ST, Seraji-Bozorgzad N, Zajac-Benitez C, Moore GJ HR-MAS 1H Magnetic resonance spectroscopic characterization of striatal oxidative metabolic failure Abst 195.1. Soc for Neuroscience, 2002 Orlando · Galloway MP*, Seraji-Bozorgzad N, Fricke ST, Mitchell TR, Schoener EP, Moore GJ Differential effects of MDMA on GABA and glutamate in rat brain: Ex vivo analysis with high-resolution magic angle spinning magnetic resonance spectroscopy (HR-MAS-1H-MRS). Abst 135.11. Soc for Neuroscience, 2002, Orlando · Galloway MP*, Mitchell TR, Seraji-Bozorgzad N, Fricke ST, Posse S, and Moore GJ Neurochemical Utility of High Resolution Magic Angle Spinning 1H-Magnietic Resonance Spectroscopy (HR-MAS-MRS) at 11.7T: Effects of MDMA and Mitochondrial Failure in Rats. American College for Neuropsychopharmacology, 40th Ann Mtg, San Juan 2002 · Galloway MP*, Mitchell TR, Seraji-Bozorgzad N, Tancer ME, and Moore GJ Neurochemical profile of acute MDMA in the rat: Assessment with high resolution magic angle spinning 1H-Magnetic resonance spectroscopy (HR-MAS-MRS) at 11.7T. College on Problems in Drug Dependence, Annual Mtg, Bal Harbor, 2003 · Galloway MP*, Mitchel TR, Seraji-Bozorgzad N, Moore GJ. Opposite Effects Of SKF38393 And MDMA On Striatal GABA And Accumbal Myo-Inositol: Studies With 1H Magnetic Resonance Spectroscopy At 11.7T. Program No. 113.1, New Orleans: Society for Neuroscience (Nov 2003). · Moore GJ, Mitchell TR, Alfano S, Seraji-Bozorgzad N, Galloway MP*. Analysis Of MR-Visible Neurochemicals In Rat Brain: Comparison Of Monoaminergic Soma And Projection Fields. Program No. 155.14, New Orleans: Society for Neuroscience (Nov 2003). · Galloway MP*, Huffman S, Alfano S, Seraji-Bozorgzad N, Mitchell TR, Moore, GJ Assessment of Antidepressant Effects on Rat Brain GABA with High Resolution 1H Magnetic Resonance Spectroscopy at 11.7 T , American College of Neuropsychopharmacology Meeting, San Juan PR, (Dec 2003). · SK O’Leary-Moore*, TR Mitchell, AP McMechan, SN Mathison, GJ Moore, MP Galloway, & JH Hannigan. Fetal Alcohol Alters Cerebellar Neurochemistry: High-Resolution Magic Angle Spinning 1H Magnetic Resonance Spectroscopy (HR-MAS 1H MRS) at 11.7T International Soc Developmental Psychobiology Meeting, Aix-en-Provence, France (June 2004) · N. Seraji-Bozorgzad*; S. Huffman, J. Tang, G.J. Moore, M.P. Galloway Effects of SSRI Antidepressants On HR-MAS 1H-MRS Metabolomic Profile In Rat Brain At 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · T.W. Uhde*, M.P. Galloway, J. Fang, T.R. Mitchell, E.O. Bixler, G.J. Moore. Sleep Deprivation Increases Excitatory Amino Acids in the Prefrontal Cortex: Studies with Magnetic Resonance Spectroscopy at 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · S. K. O’Leary-Moore*, N. Seraji-Bozorgzad, T.R. Mitchell, G.J. Moore, M.P. Galloway, & J. H. Hannigan. Developmental Changes in Regional Neurochemistry Using High-Resolution Magic Angle Spinning 1H-Magnetic Resonance Spectroscopy (HR-MAS 1H MRS) at 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · M.P. Galloway, S. Huffman, K.M. Haubenreich*, M.J. Brucal*, N. Seraji-Bozorgzad, T.R. Mitchell, G.J. Moore. Neurochemical Profile Of Dopamine Cell Loss After 6OHDA or MPTP: Analysis With 1H Magnetic Resonance Spectroscopy At 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · R.R. Maan*; J. Tang, N. Seraji-Bozorgzad, T.R. Mitchell, G.J. Moore, M.P. Galloway Neurochemical Profile Of Cocaine In The Rat: Metabolomic Analysis With 1H Magnetic Resonance Spectroscopy At 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · T.R. Mitchell*, J. Tang, N. Seraji-Bozorgzad, M.P. Galloway, G.J. Moore Neuroprotection Afforded By Lithium Against 3-Nitroproprionic Acid: Neurochemical And Anatomical Studies With Magnetic Resonance At 11.7 Tesla. Society for Neuroscience (Oct 2004) San Diego, CA · G.M. McKelvey*, H.M. Marsh, A. Pustavoitau, T.R. Mitchell, N. Seraji-Bozorgzad, G.J. Moore, M.P. Galloway. Common Effects Of Halothane And Isofluorane On The Neurochemical Profile Rat Brain: Studies With High-Resolution Magic Angle Spinning 1H-Magnetic Resonance Spectroscopy (HR-MAS-1H-MRS) At 11.7T. Society for Neuroscience (Oct 2004) San Diego, CA · T. Uhde, M. Galloway*, J Fang, T. Mitchell, E. Bixler, B. Cortese, R. Singareddy, A Vgontzas, M McEchron, G. Moore. Sleep Deprivation and Excitatory Amino Acids, American College of Neuropsychopharmacology Annual Mtg, San Juan PR, (Dec 2004). · N. Seraji-Bozorgzad, KM Haubenreich, J Tang, GJ Moore, and MP Galloway*. Correlations between the neurochemical profile determined with 1H-magnetic resonance spectroscopy at 11.7 T and dopamine and serotonin activity in rat brain: Effects of challenge with serotonergic agents, American College of Neuropsychopharmacology Annual Mtg, San Juan PR, (Dec 2004). · Mitchell TR*, Seraji-Bozorgzad N, Galloway MP, Moore GJ Mood Stabilizers Protect Against a Huntington's Disease Animal Model: A Multi-Modal MR Study at 11.7 T. 13th Ann Mtg of International Society for Magnetic Resonance in Medicine, Miami FL (May 2005) · KL Murphy*, G. McKelvey, A. Pustavoitau, N. Seraji-Bozorgzad, MP Galloway, HM Marsh The Effects of Volatile and Injectable Anesthetics on the Neurochemical Profile in Rat Brain: Studies with High Resolution Magic Angle Spinning 1H Magnetic Resonance Spectroscopy (HR-MAS-1H-MRS) at 11.7 T 52nd Ann Mtg Assoc University Anesthesiologists Baltimore MD, (May 2005). · S K O’Leary-Moore*, N. Seraji-Bozorgzad, M P Galloway, and JH Hannigan Neurochemical profile of fetal alcohol exposure: Analysis with 1H-magnetic resonance spectroscopy at 11.7 Tesla. Research Society on Alcoholism 28th Annual Mtg, Santa Barbara CA (June 2005) · GM McKelvey*; KL Murphy, A. Pustavoitau, N. Seraji-Bozorgzad, KE Prevost, SK O'Leary Moore, GL Moore, HM Marsh, MP Galloway. NMDA receptor antagonism with ketamine selectively increases GABA measured with proton magnetic resonance spectroscopy. Society for Neuroscience (Nov 2005) Washington, DC · KL Murphy*; GM McKelvey, SK O'Leary-Moore, N. Seraji-Bozorgzad, DC Freeman, A. Pustavoitau, KM. Haubenreich, GJ Moore, HM Marsh, MP Galloway. Potentiation of GABA-A receptor function with propofol selectively decreases glutamate measured with proton magnetic resonance spectroscopy. Society for Neuroscience (Nov 2005) Washington, DC · MP Galloway*; SK O'Leary-Moore, N Seraji-Bozorgzad, HM Moore, GM Miller, SG Rayport. Probing the Nature of MR-Visible Neurochemicals using Trangenic Mice Lacking Glutaminase and High-Resolution Magic Angle Spinning 1H Magnetic Resonance Spectroscopy. Society for Neuroscience (Nov 2005) Washington, DC · N. Seraji-Bozorgzad*; S. O'Leary-Moore; MP Galloway. Coupling of MR visible GABA, glutamate and glutamine to metabolic and neuronal pathways. Society for Neuroscience (Nov 2005) Washington, DC · S.K. O'Leary-Moore*, AP McMechan, N. Seraji-Bozorgzad, KE Prevost, JH Hannigan, MP Galloway. Acute Ethanol Exposure Alters the Metabolomic Profile in Rat Brain as Measured by Magic Angle Spinning 1H Magnetic Resonance Spectroscopy (HRMAS 1H MRS) Society for Neuroscience (Nov 2005) Washington, DC · SK O’Leary-Moore*, AP McMechan, DR Williams, MP Galloway, JH Hannigan, SE Bowen Region-Dependent Alterations in Brain Glutamate, GABA and Glutamine Levels after Acute Toluene Exposure in Juvenile Rats Measured by High-Resolution 1H Magnetic Resonance Spectroscopy at 11.7 Tesla International Soc Developmental Psychobiology Meeting (Nov 2005) Wash, DC · Galloway, MP*; Seraji-Bozorgzad, N; Murphy, KL; O'Leary Moore, SK; Haubenreich, KM; McKelvey, GM; Pustavoitau, A; Hannigan, JH; Marsh, HM. Increased GABAergic Activity Modulates MR-Visible Glutamate and Glutamine: Studies with High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HR-MAS 1H-MRS) American College of Neuropsychopharmacology Annual Mtg, Waikolao, HI, (Dec 2005). · Bustillo, JR*; Perrone-Bizzozero, N, Paz, R, Griffith, G, Galloway, M Hypometabolic medial-frontal effects of chronic intermittent PCP exposure in rats assessed with high resolution magic angle spin 11.7T proton magnetic resonance spectroscopy American College of Neuropsychopharmacology Annual Mtg, Waikolao, HI, (Dec 2005).
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