Matcheri S. Keshavan

Matcheri S. Keshavan M.D.

Professor and Co-Director STEP Programs
Department of Psychiatry and Behavioral Neurosciences
Wayne State University School of Medicine
9B 4201 St. Antoine Boulevard Detroit, MI 48201

E mail: mkeshava@med.wayne.edu

Phone: (313) 993-6732

Fax: (313) 577-5900

Education:

MD Mysore University India 1977

Residency National Institute of Mental Health and Neurosciences, Bangalore, India 1979; Maudsley Hospital London UK 1985

Research Interests:

Neuroimaging Research Interests are focused on the structural, functional and neurochemical basis of severe mental disorders such as schizophrenia, bipolar disorders and other developmental Neuropsychiatric disorders . Techniques such as Magnetic resonance spectroscopy and functional magnetic resonance neuroimaging are used to investigate these disorders.

Clinical research interests include early intervention in schizophrenia, especially as it pertains to the premorbid and prodromal phases of this illness. These studies are conducted as part of the Services for Treatment in Early Psychoses ( STEP) program at the Wayne State University Department of Psychiatry and Behavioral Neurosciences.To investigate possible improvements in in vivo biochemical, peripheral measurements of essential fatty acids, and attention performance of ADHD children following a dietary supplementation of a specific essential fatty acid.

Awards and Achievements:

Dr. Keshavan is closely involved in research in neurobiology of psychosis, especially as it pertains to first episode psychotic disorders. His research has resulted in over 180 publications to date, including over 180 peer-reviewed papers, three books, 20 book chapters and over 140 abstracts. He has received several awards including the Gaskell Medal of the Royal College of Psychiatrists (1985), Nancy Roschke Certificate of the APA in 1993, the Golden Apple Award for Teaching at the Department of Psychiatry in 1992 and 1994, the Research Scientist Development Award from NIMH and co-recipient of the 2003 NAMI (National Alliance for the Mentally Ill of Pennsylvania) Psychiatrist of the Year Award.

Recent Publications:

1. Yao JK, Thomas EA, Reddy RD, Keshavan MS. Association of apolipoproteins D with RBC membrane arachidonic acid levels in schizophrenia. Schizophrenia Research 72 (2005) 259- 266.

2. Reilly JL, Harris MSH, Keshavan MS, Sweeney JA. Abnormalities in Visually Guided Saccades Suggest Corticofugal Dysregulation in Never-Treated Schizophrenia. Biol Psychiatry 2005; 57:145-154.

3. Keshavan MS, Duggal HS, Veeragandham G, McLaughlin N, Montrose D, Haas G, Schooler N. Personality dimensions in first-episode psychoses. Am J Psychiatry, 2005 January 162:1.

4. Duggal HS, Muddasani S, Keshavan MS. Insular volumes in first-episode schizophrenia: gender effect. Schizophrenia Research, 73 (2005) 113-120.

5. Lacerda ALT, Caetano D, Keshavan MS. Acid urinary pH in panic disorder.Psychiatry Research, in press.

6. Schuepbach D, Keshavan MS, Hell D, Sweeney JA. Dynamic associations among symptoms, cognition and functioning through the early course of first-episode schizophrenia. The British Journal of Psychiatry, in press.

7. Jou RJ, Hardan AY, Keshavan MS. Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study. Schizophrenia Research, in press.

8. Keshavan MS, Diwadkar VA, Montrose DM, Rajarethinam R, Sweeney JA. Premorbid Indicators and Risk for Schizophrenia: A selective review and update. Schizophrenia Research, in press.

9. Keshavan MS, Berger G, Zipursky RB,Wood SJ, Pantelis C. Neurobiology of early psychoses. British Journal of Psychiatry, in Press.

10. Diwadkar VA, Montrose DM, Dworakowski D, Sweeney JA, Keshavan MS. Genetically predisposed offspring with schizotypal features

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