Shonagh K. O'Leary-Moore

Shonagh K. O'Leary-Moore

Graduate Student
Department of Psychology, Behavioral and Cognitive Neuroscience Area
Wayne State University School of Medicine

Mailing Address: Brain Research And Imaging Neurosciences (BRAINS)
                            Dept of Psychiatry and Behavioral Neurosciences
                            2126 Scott Hall 540 E. Canfield
                            Detroit, MI 48201

E mail: soleary@wayne.edu

Phone: (313) 577-6910

Fax: (313) 577-6915

EDUCATION

Wright State University, Dayton, OH	B.S., Psychology Summa Cum Laude	June, 2001
Wayne State University, Detroit, MI	M.A., Psychology (Behavioral & Cognitive Neuroscience Area) Faculty Advisor: John H. Hannigan, Ph.D. Thesis: Reversal learning and fetal alcohol exposure: Effects of time of exposure and age of testing	August, 2004

TEACHING EXPERIENCE

2002-2003	Graduate Teaching Assistant: Psychology 3060 Learning and Memory Laboratory
2003-2004	Graduate Teaching Assistant: Psychology 3010 Statistics Laboratory

MERIT AWARDS AND ACADEMIC HONORS

1998	Golden Key National Honor Society
1998	The Honor Society of Phi Kappa Phi
1998	Psi Chi Honor Society
2000	Robert C. Chollar Memorial Scholarship; College of Science and Mathematics; Wright State University
2001	Thomas C. Rumble University Fellowship; Wayne State University
2001, 2002 & 2004	Travel Award Recipient for International Society for Developmental Psychobiology
2003	Outstanding Graduate Student CS Mott Center for Human Growth and Development
2005	Fetal Alcohol Syndrome Study Group Travel Award Recipient

RESEARCH INTERESTS

My primary research interests include the behavioral and neurochemical consequences of perinatal alcohol exposure and
utilizing high-resolution magic-angle spinning 1H magnetic resonance spectroscopy (HR-MAS) at 11.7 Tesla to study neural
development following neonatal alcohol exposure.

The long-term goals of this research are to:
1) Characterize the regional metabolic profile of the normal developing rat brain using HR-MAS.
2) Examine the acute effects of alcohol exposure in the neonatal and the adult rat brain.
3) Assess how alcohol exposure during the third trimester equivalent in the rat (early postnatal exposure)
alters the neurochemical profile with a particular interest in NAA, Glu, GABA, Gln, GSH, and the membrane phospholipids.
4) Use HRMAS to test various treatments (pharmacological or environmental) to ameliorate the adverse effects of early alcohol exposure.

GRANT SUPPORT

F31 - AA15224-01 National Institute of Alcohol Abuse and Alcoholism Pre-doctoral National Research Service Award (NRSA)
Neonatal alcohol exposure and ¹H-NMR imaging in rats

PUBLICATIONS

Hennessy, M.B., Pitstick, L., O’Leary, S., Maken, D. S., and Farre, A. J. (2001) Effects of a Novel Potential Antidepressant on the Behavior
and Cortisol Levels of Isolated Guinea Pig Pups. Pharmacology, Biochemistry, and Behavior, 69, 527-533.

Hennessy, M. B., O’Leary, S. K., Hawke, J., & Wilson, S. (2002) Social Influences on Cortisol and Behavioral Responses of Preweaning,
Periadolescent and Adult Guinea Pigs. Physiology & Behavior, 76, 305-314.

Hennessy, M. B., Young, T. L., O’Leary, S. K., & Maken, D. S. (2003) Social Preferences of Developing Guinea Pigs (Cavia porcellus)
from the Preweaning to the Periadolescent Periods. Journal of Comparative Psychology, 117, 406-413.

McMechan, A. P., O’Leary-Moore, S. K., Morrison, S. D. & Hannigan, J. H. (2004). Effects of Prenatal Alcohol Exposure on Forwpaw
Digit Length and Digit Ratios in Rats. Developmental Psychobiology, 45 (4), 251-258.

O’Leary-Moore, S. K., McMechan, A. P., & Hannigan, J. H. (in preparation). Reversal Learning After Pre- and Early Postnatal Alcohol Exposure in Juvenile and Adult Rats

SELECTED ABSTRACTS

O’Leary, S. K., Hawke, J., Wilson, S., & Hennessy, M. B. (November 2001) The Effects of Various Social Partners on HPA Activity and Behavior in
Preweaning, Periadolescent, and Adult Guinea Pigs. International Society for Developmental Psychobiology (ISDP) Poster Presentation, San Diego, CA.

Hannigan, J. H., O’Leary, S. K., & Berman, R. F. (June 2002). Persistence of Prenatal Alcohol-Induced Neurobehavioral Deficits: Modification by Postnatal Experience.
Neurobehavioral Teratology Society Presentation, Scottsdale, AZ.

O’Leary, S. K., McMechan, A. P., Morrison, S., Berman, R. F. & Hannigan, J. H. (July 2002). Reversal Learning in Adult Rats Prenatally Exposed to Alcohol.
Research Society on Alcoholism Poster Presentation, San Francisco, CA. Alcoholism: Clinical and Experimental Research 26, 179A, Abstract #1042.

O’Leary, S. K., McMechan, A. P., Berman, R. F. & Hannigan, J. H. (October 2002). Persistence of Environmental Enrichment Effects after Prenatal
Alcohol Exposure on Morris Water Maze Performance. International Society for Developmental Psychobiology Poster Presentation and slide session,
Orlando, FL. Developmental Psychobiology 41, 318, Abstract #84.

Hannigan, J. H., O’Leary, S.K. Greenberry, A., Morrison, S. D., McMechan, A. P. & Batis, J.C. (October 2002). Maternal-Pup Interactions Following
Prenatal Alcohol Exposure and Neonatal Handling. International Society for Developmental Psychobiology Poster Presentation, Orlando, FL.
Developmental Psychobiology, 41, 306, Abst. #38.

O’Leary, S. K., Morrison, S. D., McMechan, A. P., Greenberry, A. L., Berman, R. F., & Hannigan, J. H. (June 2003) Prenatal Alcohol Exposure and Age:
Effects on a Reversal Learning Task. Research Society on Alcoholism poster presentation, Ft. Lauderdale, FL.
Alcoholism: Clinical and Experimental Research 27, 42A, Abstract #220.

O’Leary-Moore, S.K., Mathison, N., McMechan, A.P., Morrison, S.D., Berman, R.F., Hannigan, J.H. (November, 2003) Reversal learning performance
after pre- and early postnatal alcohol exposure. International Society for Developmental Psychobiology Poster Presentation, New Orleans, LA.

O’Leary-Moore, S. K., Mitchell, T. R., McMechan, A. P., Mathison, S. N., Moore, G. J., Galloway, M. P. & Hannigan, J. H. . (June, 2004) Fetal alcohol alters
cerebellar neurochemistry: High resolution magic-angle spinning proton magnetic resonance spectroscopy (HR-MAS ¹H MRS) at 11.7T.
International Society for Developmental Psychobiology Poster Presentation, Aix-en-Provence, France.

SK O’Leary-Moore, N. Seraji-Bozorgzad, TR Mitchell, GJ Moore, MP Galloway, & JH Hannigan (November 2004)
Developmental Changes in Regional Neurochemistry Using High-Resolution Magic Angle Spinning 1H-Magnetic Resonance Spectroscopy
(HR-MAS 1H MRS) at 11.7T. Society for Neuroscience Poster Presentation. San Diego, CA.

SK O’Leary-Moore, N. Seraji-Bozorgzad, MP Galloway, & JH Hannigan (June 2005) Neurochemical Profile of Fetal Alcohol Exposure:
Analyses with 1H-Magnetic Resonance Spectroscopy at 11.7T. Research Society on Alcoholism Poster Presentation and Fetal Alcohol Study Group
FAST data session participant. Santa Barbara, CA.

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